A topoisomerase inhibitor that inhibits DNA topoisomerase (ATP-hydrolysing), EC 5.99.1.3 (also known as topoisomerase II and as DNA gyrase), which catalyses ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands.
| Member | Definition | Class |
|---|
| aclarubicin | An anthracycline antibiotic that is produced by Streptomyces galilaeus and also has potent antineoplastic activity. | aclacinomycin A zwitterion; aclacinomycin A |
| aclarubicin | A zwitterion obtained by transfer of a proton from the 5-hydroxy to the tertiary amino group of aclacinomycin A. It is the major microspecies at pH 7.3 (according to Marvin v 6.2.0.). | aclacinomycin A zwitterion; aclacinomycin A |
| amsacrine | A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity. | amsacrine |
| betulinic acid | A pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-carboxy substituents. It is found in the bark and other plant parts of several species of plants including Syzygium claviflorum. It exhibits anti-HIV, antimalarial, antineoplastic and anti-inflammatory properties. | betulinic acid |
| celastrol | A pentacyclic triterpenoid that is 24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid bearing an oxo substituent at position 2, a hydroxy substituent at position 3 and two methyl groups at positions 9 and 13. An antioxidant and anti-inflammatory agent. Potently inhibits lipid peroxidation in mitochondria and inhibits TNF-alpha-induced NFkappaB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 muM). | celastrol |
| ciprofloxacin | A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively. | ciprofloxacin zwitterion; ciprofloxacin |
| ciprofloxacin hydrochloride anhydrous | The anhydrous form of the monohydrochloride salt of ciprofloxacin. | ciprofloxacin hydrochloride (anhydrous) |
| dihydrobetulinic acid | A pentacyclic triterpenoid that is lupane having a 3beta-hydroxy and 28-carboxy substituents. Isolated from the leaves of Syzygium claviflorum, it exhibits anti-HIV and antileishmanial activity. | dihydrobetulinic acid |
| ellagic acid | An organic heterotetracyclic compound resulting from the formal dimerisation of gallic acid by oxidative aromatic coupling with intramolecular lactonisation of both carboxylic acid groups of the resulting biaryl. It is found in many fruits and vegetables, including raspberries, strawberries, cranberries, and pomegranates. | ellagic acid |
| epirubicin | An anthracycline that is the 4'-epi-isomer of doxorubicin. | 4'-epidoxorubicin |
| fisetin | A 7-hydroxyflavonol with additional hydroxy groups at positions 3, 3' and 4'. | fisetin |
| fleroxacin | A fluoroquinolone antibiotic that is 4-oxo-1,4-dihydroquinoline which is substituted at positions 1, 3, 6, 7 and 8 by 2-fluoroethyl, carboxy, fluoro, 4-methylpiperazin-1-yl and fluoro groups, respectively. It is active against many Gram-positive and Gram-negative bacteria. | fleroxacin |
| gatifloxacin | A monocarboxylic acid that is 4-oxo-1,4-dihydroquinoline-3-carboxylic acid which is substituted on the nitrogen by a cyclopropyl group and at positions 6, 7, and 8 by fluoro, 3-methylpiperazin-1-yl, and methoxy groups, respectively. Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial topoisomerase type-II enzymes. | gatifloxacin |
| genistein | A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties. | genistein |
| levofloxacin | An optically active form of ofloxacin having (S)-configuration; an inhibitor of bacterial topoisomerase IV and DNA gyrase. | levofloxacin |
| lucanthone | A thioxanthen-9-one compound having a methyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. Formerly used for the treatment of schistosomiasis. It is a prodrug, being metabolised to hycanthone. | lucanthone |
| maleimide | A cyclic dicarboximide in which the two carboacyl groups on nitrogen together with the nitogen itself form a 1H-pyrrole-2,5-dione structure. | maleimide |
| manoalide | A sesterterpenoid isolated from the marine sponge Luffariella variabilis and which has been shown to exhibit inhibitory activity towards phospholipase A2. | manoalide |
| methyl brevifolincarboxylate | An organic heterotricyclic compound that is 1,2,3,5-tetrahydrocyclopenta[c]isochromene substituted by hydroxy groups at positions 7, 8 and 9, oxo groups at positions 3 and 5 and a methoxycarbonyl group at position 1. Isolated from Phyllanthus urinaria and Phyllanthus niruri, it exhibits vasorelaxant activity. | methyl brevifolincarboxylate |
| novobiocin | A coumarin-derived antibiotic obtained from Streptomyces niveus. | novobiocin |
| teniposide | A furonaphthodioxole that is a synthetic derivative of podophyllotoxin with anti-tumour activity; causes single- and double-stranded breaks in DNA and DNA-protein cross-links and prevents repair by topoisomerase II binding. | teniposide |
| top 53 | A furonaphthodioxole that is 4'-demethyldeoxypodophyllotoxin which is substituted at position 4 of the C-ring by a 2-{[2-(dimethylamino)ethyl](methyl)amino}ethyl group. While structurally related to etoposide, TOP-53 is significantly more toxic to non-small cell lung cancer cells, more active at generating chromosomal breaks, and displays improved cellular uptake and pharmacokinetics in animal lung tissues. | TOP-53 |
| wedelolactone | A member of the class of coumestans that is coumestan with hydroxy substituents as positions 1, 8 and 9 and a methoxy substituent at position 3. | wedelolactone |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 16.7340 | 1 | 12 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 13.9245 | 1 | 6 |
| 67.9K protein | Vaccinia virus | Potency | 17.9478 | 2 | 4 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 73.3786 | 2 | 2 |
| acid sphingomyelinase | Homo sapiens (human) | Potency | 562.3410 | 1 | 1 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 35.6481 | 2 | 3 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 25.2130 | 1 | 5 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 44.6684 | 1 | 2 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 0.7943 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 18.8086 | 12 | 34 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 10.6446 | 3 | 6 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 15.0093 | 4 | 6 |
| Ataxin-2 | Homo sapiens (human) | Potency | 19.2824 | 2 | 6 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 16.9441 | 1 | 1 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 25.8724 | 2 | 8 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 7.0484 | 2 | 7 |
| BRCA1 | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 0.7943 | 1 | 1 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 70.4072 | 1 | 1 |
| caspase-1 isoform alpha precursor | Homo sapiens (human) | Potency | 18.9389 | 1 | 3 |
| caspase-3 | Homo sapiens (human) | Potency | 70.4072 | 1 | 1 |
| Caspase-7 | Homo sapiens (human) | Potency | 17.2168 | 1 | 3 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 36.4224 | 2 | 8 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 12.2999 | 2 | 10 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 12.3871 | 1 | 9 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 3.9411 | 3 | 10 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 30.9288 | 1 | 2 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 25.1189 | 1 | 2 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 34.1729 | 2 | 3 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 19.3005 | 2 | 13 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 44.9165 | 1 | 2 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 9.8898 | 3 | 12 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 14.1596 | 2 | 6 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 15.4477 | 2 | 9 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 19.3005 | 2 | 13 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 31.5194 | 2 | 3 |
| core-binding factor subunit beta isoform 2 | Homo sapiens (human) | Potency | 14.1974 | 3 | 5 |
| CREB-binding protein | Homo sapiens (human) | Potency | 17.0453 | 2 | 4 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 20.5251 | 1 | 3 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 18.5101 | 1 | 6 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 6.2121 | 1 | 2 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 21.7078 | 1 | 2 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 21.0830 | 2 | 10 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 6.7291 | 2 | 4 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 5.2996 | 1 | 4 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 0.6428 | 2 | 2 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Potency | 3.6898 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3F isoform a | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 37.1700 | 1 | 4 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 0.7943 | 1 | 1 |
| DNA polymerase III, partial | Bacillus subtilis | Potency | 29.9349 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 0.6110 | 1 | 2 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 0.6524 | 1 | 7 |
| endonuclease IV | Escherichia coli | Potency | 12.9884 | 1 | 4 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 22.7097 | 12 | 46 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 13.3711 | 3 | 9 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 13.9654 | 10 | 29 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 11.9131 | 1 | 5 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 8.5180 | 4 | 19 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 34.7127 | 3 | 7 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 24.6973 | 1 | 5 |
| fructose-bisphosphate aldolase A | Oryctolagus cuniculus (rabbit) | Potency | 63.0957 | 1 | 1 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 2.5730 | 1 | 3 |
| G | Vesicular stomatitis virus | Potency | 6.2121 | 1 | 2 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 21.0830 | 1 | 5 |
| GALC protein | Homo sapiens (human) | Potency | 0.7079 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 21.0830 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 21.0830 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 21.0830 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 21.0830 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 21.0830 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 21.0830 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 21.0830 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 21.0830 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 21.0830 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 21.0830 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 21.0830 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 21.0830 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 21.0830 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 21.0830 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 21.0830 | 1 | 5 |
| geminin | Homo sapiens (human) | Potency | 11.8969 | 2 | 6 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 10.0660 | 2 | 10 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 13.3519 | 2 | 2 |
| GLS protein | Homo sapiens (human) | Potency | 5.4692 | 2 | 3 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 17.6558 | 1 | 4 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 24.4336 | 2 | 7 |
| glucokinase regulatory protein | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | Potency | 1.7907 | 1 | 3 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 9.9463 | 2 | 7 |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | Potency | 1.7907 | 1 | 3 |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | Potency | 1.7907 | 1 | 3 |
| glyceraldehyde-3-phosphate dehydrogenase isoform 1 | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 23.7117 | 2 | 6 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 29.9893 | 2 | 2 |
| hemoglobin subunit beta | Homo sapiens (human) | Potency | 20.8114 | 1 | 2 |
| hexokinase-4 isoform 1 | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 15.8340 | 2 | 24 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 23.6952 | 1 | 3 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 8.9840 | 2 | 6 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 66.8914 | 2 | 9 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 6.2121 | 1 | 2 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 19.4151 | 2 | 2 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 5.0119 | 2 | 4 |
| IDH1 | Homo sapiens (human) | Potency | 11.6196 | 1 | 2 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 70.8704 | 1 | 2 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 6.2121 | 1 | 4 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 13.5346 | 2 | 2 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 10.5801 | 1 | 5 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 10.5801 | 1 | 5 |
| Interferon beta | Homo sapiens (human) | Potency | 12.1160 | 3 | 18 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 12.4850 | 2 | 6 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 14.4504 | 1 | 4 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 18.5960 | 3 | 9 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 4.4668 | 1 | 1 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 56.2341 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 18.0599 | 2 | 13 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 9.1286 | 2 | 5 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 8.1548 | 2 | 2 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 5.1358 | 1 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 13.0910 | 4 | 15 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 20.0245 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 19.9421 | 2 | 4 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 19.7919 | 3 | 12 |
| Ornithine decarboxylase | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 1 | 1 |
| P53 | Homo sapiens (human) | Potency | 2.5119 | 1 | 1 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 56.4667 | 1 | 3 |
| Parkin | Homo sapiens (human) | Potency | 14.3978 | 2 | 2 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 1.2589 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 15.1014 | 2 | 2 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 16.9441 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 36.8764 | 4 | 9 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 37.5339 | 5 | 9 |
| phosphoglycerate kinase | Trypanosoma brucei brucei TREU927 | Potency | 0.8913 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 43.1512 | 1 | 5 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 10.6101 | 1 | 2 |
| polyprotein | Zika virus | Potency | 2.5730 | 1 | 3 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 7.8058 | 1 | 3 |
| PPM1D protein | Homo sapiens (human) | Potency | 12.7194 | 1 | 10 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 41.9710 | 2 | 6 |
| progesterone receptor | Homo sapiens (human) | Potency | 23.5178 | 1 | 4 |
| putative alpha-glucosidase | Oryza sativa Japonica Group (Japanese rice) | Potency | 44.6684 | 1 | 2 |
| pyruvate kinase | Leishmania mexicana mexicana | Potency | 12.5893 | 2 | 2 |
| pyruvate kinase PKM isoform b | Homo sapiens (human) | Potency | 25.1189 | 2 | 2 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 59.9763 | 1 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 6.0918 | 2 | 10 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 29.8828 | 1 | 3 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 53.9290 | 1 | 3 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 4.2912 | 3 | 13 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 21.3184 | 4 | 11 |
| runt-related transcription factor 1 isoform AML1b | Homo sapiens (human) | Potency | 14.1974 | 3 | 5 |
| serine-protein kinase ATM isoform a | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 1.4473 | 3 | 3 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 19.1858 | 1 | 2 |
| shiga toxin 1 B subunit | Escherichia coli O157:H7 | Potency | 7.9805 | 1 | 1 |
| shiga toxin 1 variant A subunit | Escherichia coli O157:H7 | Potency | 25.7220 | 3 | 3 |
| signal transducer and activator of transcription 6, interleukin-4 induced | Homo sapiens (human) | Potency | 25.1189 | 3 | 3 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 34.6084 | 2 | 3 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 34.6084 | 2 | 3 |
| Smad3 | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| snurportin-1 | Homo sapiens (human) | Potency | 70.8704 | 1 | 2 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 14.2184 | 2 | 8 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 25.2300 | 1 | 3 |
| TDP1 protein | Homo sapiens (human) | Potency | 15.1406 | 2 | 24 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 0.8913 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 26.5784 | 3 | 7 |
| Thrombopoietin | Homo sapiens (human) | Potency | 2.0484 | 2 | 4 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 19.1567 | 3 | 10 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 31.7239 | 3 | 6 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 29.7508 | 6 | 8 |
| tyrosine-protein kinase Yes | Homo sapiens (human) | Potency | 30.7475 | 1 | 1 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 1.1220 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 10.6101 | 1 | 2 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 10.6101 | 1 | 2 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 33.8216 | 2 | 3 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 39.9541 | 1 | 1 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 10.8973 | 4 | 6 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 39.8107 | 1 | 4 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 16.0630 | 1 | 4 |
| Vpr | Human immunodeficiency virus 1 | Potency | 11.2202 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| [tau protein] kinase | Oryctolagus cuniculus (rabbit) | IC50 | 6.0000 | 1 | 1 |
| 1-deoxy-D-xylulose 5-phosphate reductoisomerase | Escherichia coli K-12 | IC50 | 3.5000 | 1 | 1 |
| 17-beta-hydroxysteroid dehydrogenase type 1 | Homo sapiens (human) | IC50 | 2.2100 | 1 | 1 |
| 17-beta-hydroxysteroid dehydrogenase type 2 | Homo sapiens (human) | IC50 | 16.5000 | 2 | 2 |
| 3-oxoacyl-acyl-carrier protein reductase | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 4.1000 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | IC50 | 10.4690 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 2.9910 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 1.1060 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 0.7040 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | IC50 | 14.9100 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 7.8060 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | IC50 | 14.9100 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | Ki | 7.8060 | 1 | 1 |
| 5-hydroxytryptamine receptor 7 | Cavia porcellus (domestic guinea pig) | IC50 | 5.0000 | 1 | 2 |
| 5'-nucleotidase | Homo sapiens (human) | IC50 | 4.5650 | 2 | 2 |
| 5'-nucleotidase | Mus musculus (house mouse) | IC50 | 34.4150 | 2 | 2 |
| 72 kDa type IV collagenase | Homo sapiens (human) | IC50 | 9.9000 | 1 | 1 |
| acetyl-CoA acetyltransferase/HMG-CoA reductase | Enterococcus faecalis | IC50 | 1,265.3900 | 1 | 1 |
| Acetylcholinesterase | Electrophorus electricus (electric eel) | IC50 | 132.9200 | 1 | 1 |
| Acetylcholinesterase | Rattus norvegicus (Norway rat) | IC50 | 50.0000 | 1 | 1 |
| Acetylcholinesterase | Homo sapiens (human) | Ki | 100.2000 | 1 | 1 |
| Acidic phospholipase A2 2 | Naja naja (Indian cobra) | IC50 | 17.0000 | 1 | 1 |
| Acidic phospholipase A2 beta | Crotalus adamanteus (eastern diamondback rattlesnake) | IC50 | 0.4000 | 1 | 1 |
| Adenosine receptor A1 | Homo sapiens (human) | IC50 | 19.9040 | 1 | 1 |
| Adenosine receptor A1 | Homo sapiens (human) | Ki | 11.6110 | 1 | 1 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | Ki | 10.5700 | 3 | 3 |
| Adenosine receptor A2a | Homo sapiens (human) | IC50 | 17.4420 | 1 | 1 |
| Adenosine receptor A2a | Homo sapiens (human) | Ki | 9.7920 | 1 | 1 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | Ki | 17.0767 | 3 | 3 |
| Aldehyde oxidase | Homo sapiens (human) | IC50 | 1.7700 | 1 | 2 |
| Aldehyde oxidase 1 | Cavia porcellus (domestic guinea pig) | Ki | 4.5300 | 1 | 1 |
| Aldehyde oxidase 1 | Oryctolagus cuniculus (rabbit) | Ki | 0.0600 | 1 | 1 |
| Aldehyde oxidase 1 | Rattus norvegicus (Norway rat) | IC50 | 6.4000 | 1 | 1 |
| Aldehyde oxidase 1 | Rattus norvegicus (Norway rat) | Ki | 3.0000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | IC50 | 10.4000 | 2 | 3 |
| Aldo-keto reductase family 1 member B10 | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| ALK tyrosine kinase receptor | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Alpha-amylase 1A | Homo sapiens (human) | IC50 | 19.6000 | 2 | 2 |
| Alpha-glucosidase MAL32 | Saccharomyces cerevisiae S288C | IC50 | 61.0000 | 1 | 2 |
| Alpha-mannosidase | Canavalia ensiformis (jack bean) | IC50 | 49.0000 | 1 | 1 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | IC50 | 4.1840 | 5 | 5 |
| Amine oxidase [flavin-containing] A | Bos taurus (cattle) | IC50 | 95.0000 | 1 | 1 |
| Amine oxidase [flavin-containing] A | Rattus norvegicus (Norway rat) | IC50 | 40.0000 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Bos taurus (cattle) | IC50 | 95.0000 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | IC50 | 3.9333 | 3 | 3 |
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 | 200.0000 | 2 | 2 |
| Androgen receptor | Homo sapiens (human) | IC50 | 1,300.0000 | 1 | 1 |
| Androgen receptor | Rattus norvegicus (Norway rat) | IC50 | 85.1138 | 1 | 1 |
| Angiopoietin-1 receptor | Homo sapiens (human) | IC50 | 0.2600 | 1 | 1 |
| Angiotensin-converting enzyme | Homo sapiens (human) | IC50 | 5,000.0000 | 1 | 1 |
| Angiotensin-converting enzyme | Homo sapiens (human) | Ki | 167.0000 | 1 | 1 |
| Arachidonate 5-lipoxygenase | Sus scrofa (pig) | IC50 | 2,500.0000 | 1 | 1 |
| Aromatase | Homo sapiens (human) | Ki | 111.5000 | 2 | 2 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 114.2667 | 1 | 6 |
| Aurora kinase A | Homo sapiens (human) | IC50 | 2.4800 | 1 | 1 |
| Aurora kinase B | Homo sapiens (human) | IC50 | 2.5650 | 2 | 2 |
| Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein) | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 4.5000 | 1 | 2 |
| Beta-secretase 1 | Homo sapiens (human) | IC50 | 3.9000 | 1 | 1 |
| Bifunctional epoxide hydrolase 2 | Homo sapiens (human) | IC50 | 20.7000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 393.3000 | 4 | 10 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| Botulinum neurotoxin type A | Clostridium botulinum | IC50 | 20.0000 | 1 | 1 |
| Botulinum neurotoxin type A | Clostridium botulinum | Ki | 14.3000 | 1 | 1 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | IC50 | 46.0956 | 7 | 7 |
| C-C chemokine receptor type 6 | Homo sapiens (human) | IC50 | 22.8000 | 1 | 1 |
| cAMP-dependent protein kinase catalytic subunit alpha | Bos taurus (cattle) | IC50 | 0.6000 | 1 | 1 |
| cAMP-dependent protein kinase catalytic subunit alpha | Homo sapiens (human) | IC50 | 39.9000 | 3 | 9 |
| cAMP-dependent protein kinase catalytic subunit beta | Homo sapiens (human) | IC50 | 2.0500 | 2 | 2 |
| cAMP-dependent protein kinase catalytic subunit gamma | Homo sapiens (human) | IC50 | 2.0500 | 2 | 2 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 6 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 105.8800 | 3 | 4 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 9.1250 | 2 | 2 |
| Carbonic anhydrase 13 | Homo sapiens (human) | Ki | 4.2400 | 1 | 1 |
| Carbonic anhydrase 13 | Mus musculus (house mouse) | Ki | 10.3000 | 1 | 1 |
| Carbonic anhydrase 14 | Homo sapiens (human) | Ki | 8.9100 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 113.7950 | 3 | 4 |
| Carbonic anhydrase 3 | Homo sapiens (human) | Ki | 10.5000 | 1 | 1 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 9.0800 | 1 | 1 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 7.5900 | 1 | 1 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | Ki | 12.7000 | 1 | 1 |
| Carbonic anhydrase 6 | Homo sapiens (human) | Ki | 7.0600 | 1 | 1 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 7.5550 | 2 | 2 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 44.5850 | 2 | 2 |
| Carbonyl reductase [NADPH] 1 | Homo sapiens (human) | IC50 | 3.7800 | 1 | 1 |
| Carbonyl reductase [NADPH] 1 | Homo sapiens (human) | Ki | 0.6000 | 1 | 1 |
| Carboxylic ester hydrolase | Rattus norvegicus (Norway rat) | IC50 | 50.0000 | 1 | 1 |
| Casein kinase II subunit alpha | Homo sapiens (human) | IC50 | 0.3033 | 6 | 6 |
| Casein kinase II subunit alpha | Homo sapiens (human) | Ki | 0.1800 | 2 | 3 |
| Casein kinase II subunit alpha | Rattus norvegicus (Norway rat) | IC50 | 0.0400 | 1 | 1 |
| Casein kinase II subunit alpha 3 | Homo sapiens (human) | IC50 | 0.3500 | 1 | 1 |
| Casein kinase II subunit alpha' | Homo sapiens (human) | IC50 | 0.3560 | 5 | 5 |
| Casein kinase II subunit alpha' | Homo sapiens (human) | Ki | 0.1700 | 1 | 1 |
| Casein kinase II subunit beta | Homo sapiens (human) | IC50 | 0.3560 | 5 | 5 |
| Casein kinase II subunit beta | Rattus norvegicus (Norway rat) | IC50 | 0.0400 | 1 | 1 |
| Casein kinase II subunit beta | Homo sapiens (human) | Ki | 0.1700 | 1 | 1 |
| Chain A, Casein kinase II subunit alpha | Homo sapiens (human) | Ki | 0.0200 | 1 | 1 |
| Chain A, Estrogen receptor 1 (alpha) | Homo sapiens (human) | IC50 | 0.0090 | 1 | 1 |
| Chain B, Cell division protein kinase 6 | Homo sapiens (human) | IC50 | 0.8500 | 1 | 1 |
| Cruzipain | Trypanosoma cruzi | IC50 | 142.7833 | 6 | 6 |
| Cyclin homolog | Herpesvirus saimiri (strain 11) | IC50 | 0.6575 | 1 | 4 |
| Cyclin-A1 | Homo sapiens (human) | IC50 | 3.3900 | 1 | 1 |
| Cyclin-A2 | Homo sapiens (human) | IC50 | 3.3900 | 1 | 1 |
| Cyclin-dependent kinase 1 | Homo sapiens (human) | IC50 | 185.3950 | 2 | 2 |
| Cyclin-dependent kinase 1 | Oryzias latipes (Japanese medaka) | IC50 | 0.6575 | 1 | 4 |
| Cyclin-dependent kinase 2 | Homo sapiens (human) | IC50 | 4.1950 | 2 | 2 |
| Cyclin-dependent kinase 4 | Homo sapiens (human) | IC50 | 125.5450 | 2 | 2 |
| Cyclin-dependent kinase 5 activator 1 | Homo sapiens (human) | IC50 | 0.6400 | 2 | 5 |
| Cyclin-dependent kinase 6 | Homo sapiens (human) | IC50 | 0.6960 | 2 | 5 |
| Cyclin-dependent-like kinase 5 | Homo sapiens (human) | IC50 | 0.6400 | 2 | 5 |
| Cysteine protease ATG4B | Homo sapiens (human) | IC50 | 4.2500 | 2 | 2 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 43.8628 | 2 | 2 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 18.8675 | 3 | 4 |
| Cytochrome P450 2D6 | Homo sapiens (human) | Ki | 4.7250 | 2 | 2 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 29.3452 | 3 | 3 |
| Cytoplasmic tyrosine-protein kinase BMX | Homo sapiens (human) | IC50 | 67.9900 | 1 | 1 |
| Death-associated protein kinase 1 | Homo sapiens (human) | IC50 | 98.0000 | 1 | 1 |
| Dipeptidyl peptidase 3 | Homo sapiens (human) | IC50 | 30.7500 | 1 | 2 |
| Dipeptidyl peptidase 4 | Homo sapiens (human) | IC50 | 0.4800 | 1 | 1 |
| Dipeptidyl peptidase 4 | Rattus norvegicus (Norway rat) | IC50 | 39.0000 | 1 | 1 |
| DNA (cytosine-5)-methyltransferase 1 | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| DNA (cytosine-5)-methyltransferase 3-like | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| DNA (cytosine-5)-methyltransferase 3A | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | IC50 | 0.4500 | 1 | 1 |
| DNA gyrase subunit A | Bacillus subtilis subsp. subtilis str. 168 | IC50 | 6.3000 | 1 | 1 |
| DNA gyrase subunit A | Escherichia coli K-12 | IC50 | 3.8913 | 34 | 38 |
| DNA gyrase subunit A | Mycobacterium tuberculosis H37Rv | IC50 | 39.9605 | 17 | 21 |
| DNA gyrase subunit A | Staphylococcus aureus | IC50 | 62.7112 | 31 | 33 |
| DNA gyrase subunit A | Escherichia coli K-12 | Ki | 0.0447 | 1 | 3 |
| DNA gyrase subunit A | Staphylococcus aureus | Ki | 0.0360 | 2 | 4 |
| DNA gyrase subunit B | Bacillus subtilis subsp. subtilis str. 168 | IC50 | 6.3000 | 1 | 1 |
| DNA gyrase subunit B | Escherichia coli K-12 | IC50 | 0.3982 | 34 | 38 |
| DNA gyrase subunit B | Mycobacterium tuberculosis H37Rv | IC50 | 7.2901 | 13 | 13 |
| DNA gyrase subunit B | Mycolicibacterium smegmatis | IC50 | 25.8523 | 7 | 7 |
| DNA gyrase subunit B | Mycolicibacterium smegmatis MC2 155 | IC50 | 0.0460 | 1 | 1 |
| DNA gyrase subunit B | Staphylococcus aureus | IC50 | 25.6138 | 32 | 34 |
| DNA gyrase subunit B | Streptococcus pneumoniae TIGR4 | IC50 | 0.0370 | 1 | 1 |
| DNA gyrase subunit B | Escherichia coli K-12 | Ki | 0.0353 | 2 | 4 |
| DNA gyrase subunit B | Staphylococcus aureus | Ki | 0.0360 | 2 | 4 |
| DNA polymerase beta | Homo sapiens (human) | IC50 | 41.1833 | 3 | 3 |
| DNA polymerase beta | Rattus norvegicus (Norway rat) | IC50 | 10.2500 | 2 | 2 |
| DNA polymerase eta | Homo sapiens (human) | IC50 | 0.0620 | 1 | 1 |
| DNA polymerase iota | Homo sapiens (human) | IC50 | 0.0620 | 1 | 1 |
| DNA polymerase kappa | Homo sapiens (human) | IC50 | 4.5000 | 2 | 2 |
| DNA primase | Mycobacterium tuberculosis CDC1551 | IC50 | 87.5000 | 1 | 2 |
| DNA topoisomerase | Streptococcus pneumoniae | IC50 | 2.0300 | 1 | 1 |
| DNA topoisomerase 2-alpha | Homo sapiens (human) | IC50 | 106.9050 | 7 | 8 |
| DNA topoisomerase 2-beta | Homo sapiens (human) | IC50 | 22.1533 | 3 | 3 |
| DNA topoisomerase 4 subunit A | Bacillus subtilis subsp. subtilis str. 168 | IC50 | 1.7000 | 1 | 1 |
| DNA topoisomerase 4 subunit A | Escherichia coli K-12 | IC50 | 51.0000 | 1 | 1 |
| DNA topoisomerase 4 subunit A | Staphylococcus aureus | IC50 | 11.5881 | 15 | 16 |
| DNA topoisomerase 4 subunit A | Escherichia coli K-12 | Ki | 0.0447 | 1 | 3 |
| DNA topoisomerase 4 subunit B | Bacillus subtilis subsp. subtilis str. 168 | IC50 | 1.7000 | 1 | 1 |
| DNA topoisomerase 4 subunit B | Staphylococcus aureus | IC50 | 14.5675 | 12 | 12 |
| DNA topoisomerase 4 subunit B | Escherichia coli K-12 | Ki | 0.0447 | 1 | 3 |
| DNA-(apurinic or apyrimidinic site) endonuclease | Homo sapiens (human) | IC50 | 5.0000 | 2 | 2 |
| Dual specificity mitogen-activated protein kinase kinase 4 | Homo sapiens (human) | IC50 | 0.4000 | 1 | 1 |
| dual specificity protein phosphatase 3 | Homo sapiens (human) | IC50 | 1.1050 | 2 | 2 |
| dual specificity protein phosphatase 6 | Rattus norvegicus (Norway rat) | IC50 | 39.5000 | 1 | 1 |
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Ectonucleoside triphosphate diphosphohydrolase 1 | Mus musculus (house mouse) | IC50 | 0.5000 | 1 | 1 |
| ELAV-like protein 3 | Homo sapiens (human) | IC50 | 0.6000 | 1 | 1 |
| Enoyl-acyl-carrier protein reductase | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 1.0000 | 2 | 2 |
| Ephrin type-B receptor 4 | Homo sapiens (human) | IC50 | 1.8300 | 1 | 1 |
| Epidermal growth factor receptor | Homo sapiens (human) | IC50 | 27.6436 | 8 | 14 |
| Estrogen receptor | Homo sapiens (human) | IC50 | 1.3477 | 23 | 25 |
| Estrogen receptor | Homo sapiens (human) | Ki | 0.2045 | 2 | 2 |
| Estrogen receptor beta | Homo sapiens (human) | IC50 | 2.0569 | 24 | 27 |
| Estrogen receptor beta | Homo sapiens (human) | Ki | 0.0123 | 2 | 2 |
| eukaryotic translation initiation factor 4 gamma 1 isoform 4 | Homo sapiens (human) | IC50 | 47.6714 | 1 | 1 |
| eukaryotic translation initiation factor 4E isoform 1 | Mus musculus (house mouse) | IC50 | 47.6714 | 1 | 1 |
| Fatty-acid amide hydrolase 1 | Rattus norvegicus (Norway rat) | IC50 | 1,600.0000 | 2 | 2 |
| Focal adhesion kinase 1 | Homo sapiens (human) | IC50 | 3.1100 | 1 | 1 |
| G-protein coupled receptor 35 | Homo sapiens (human) | IC50 | 0.1000 | 1 | 1 |
| G1/S-specific cyclin-D1 | Homo sapiens (human) | IC50 | 125.5450 | 2 | 2 |
| G2/mitotic-specific cyclin-B | Marthasterias glacialis (spiny starfish) | IC50 | 0.6575 | 1 | 4 |
| G2/mitotic-specific cyclin-B1 | Homo sapiens (human) | IC50 | 185.3950 | 2 | 2 |
| G2/mitotic-specific cyclin-B2 | Homo sapiens (human) | IC50 | 0.7900 | 1 | 1 |
| G2/mitotic-specific cyclin-B3 | Homo sapiens (human) | IC50 | 0.7900 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | IC50 | 34.3033 | 3 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | IC50 | 34.3033 | 3 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | IC50 | 34.3033 | 3 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | IC50 | 34.3033 | 3 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | IC50 | 34.3033 | 3 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | IC50 | 34.3033 | 3 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | IC50 | 34.3033 | 3 | 6 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | IC50 | 34.3033 | 3 | 6 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | IC50 | 34.3033 | 3 | 6 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | IC50 | 34.3033 | 3 | 6 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | IC50 | 34.3033 | 3 | 6 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | IC50 | 34.3033 | 3 | 6 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | IC50 | 34.3033 | 3 | 6 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | IC50 | 34.3033 | 3 | 6 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | IC50 | 34.3033 | 3 | 6 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | IC50 | 34.3033 | 3 | 6 |
| Genome polyprotein | Hepatitis C virus (isolate BK) | IC50 | 36.0000 | 1 | 1 |
| Genome polyprotein | | IC50 | 0.7500 | 1 | 1 |
| Genome polyprotein | Zika virus | IC50 | 14.2000 | 1 | 1 |
| Glucose-6-phosphate 1-dehydrogenase | Homo sapiens (human) | IC50 | 5.1800 | 1 | 1 |
| Glucose-6-phosphate 1-dehydrogenase | Homo sapiens (human) | Ki | 4.8655 | 4 | 4 |
| Glutathione reductase, mitochondrial | Homo sapiens (human) | IC50 | 22.8000 | 1 | 1 |
| Glutathione S-transferase | Plasmodium falciparum 3D7 | IC50 | 74.4000 | 1 | 1 |
| Glutathione S-transferase Mu 1 | Mus musculus (house mouse) | IC50 | 100.0000 | 1 | 1 |
| Glutathione S-transferase P | Homo sapiens (human) | IC50 | 63.5500 | 2 | 2 |
| Glycogen phosphorylase, muscle form | Oryctolagus cuniculus (rabbit) | IC50 | 42.9145 | 3 | 4 |
| Glycogen synthase kinase-3 alpha | Homo sapiens (human) | IC50 | 3.2100 | 2 | 2 |
| Glycogen synthase kinase-3 beta | Homo sapiens (human) | IC50 | 4.6400 | 3 | 3 |
| Glycogen synthase kinase-3 beta | Rattus norvegicus (Norway rat) | IC50 | 0.6575 | 1 | 4 |
| heat shock 70kDa protein 1A | Homo sapiens (human) | IC50 | 66.9200 | 3 | 3 |
| heat shock cognate 71 kDa protein isoform 1 | Homo sapiens (human) | IC50 | 99.6000 | 2 | 2 |
| heat shock cognate 71 kDa protein isoform 2 | Homo sapiens (human) | IC50 | 99.6000 | 2 | 2 |
| Heat shock protein HSP 90 | Oryctolagus cuniculus (rabbit) | IC50 | 382.0000 | 2 | 2 |
| Heat shock protein HSP 90-beta | Homo sapiens (human) | IC50 | 231.0000 | 1 | 1 |
| Hepatocyte growth factor receptor | Homo sapiens (human) | IC50 | 0.5800 | 1 | 1 |
| Hypoxia-inducible factor 1-alpha | Homo sapiens (human) | IC50 | 0.2500 | 1 | 1 |
| Indoleamine 2,3-dioxygenase 1 | Homo sapiens (human) | IC50 | 8.4100 | 1 | 1 |
| Inhibitor of nuclear factor kappa-B kinase subunit alpha | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Inhibitor of nuclear factor kappa-B kinase subunit beta | Homo sapiens (human) | IC50 | 5.9900 | 2 | 2 |
| Insulin receptor | Homo sapiens (human) | IC50 | 0.3400 | 1 | 1 |
| Insulin-like growth factor 1 receptor | Homo sapiens (human) | IC50 | 0.2500 | 1 | 1 |
| Integrase | Human immunodeficiency virus 1 | IC50 | 23.5250 | 8 | 8 |
| L-ornithine N(5)-monooxygenase | Aspergillus fumigatus Af293 | IC50 | 11.0000 | 2 | 2 |
| Lactoylglutathione lyase | Homo sapiens (human) | Ki | 13.1826 | 1 | 1 |
| LacZ protein (plasmid) | Escherichia coli | IC50 | 66.6000 | 1 | 1 |
| likely tRNA 2'-phosphotransferase | Candida albicans SC5314 | IC50 | 0.2913 | 2 | 2 |
| M17 leucyl aminopeptidase | Plasmodium falciparum 3D7 | IC50 | 138.0800 | 1 | 1 |
| Macrophage migration inhibitory factor | Homo sapiens (human) | IC50 | 4.7700 | 1 | 1 |
| Macrophage migration inhibitory factor | Homo sapiens (human) | Ki | 1.9500 | 1 | 1 |
| Maltase-glucoamylase, intestinal | Homo sapiens (human) | IC50 | 6.5050 | 2 | 2 |
| Maltase-glucoamylase, intestinal | Homo sapiens (human) | Ki | 10.4000 | 1 | 1 |
| Mcl-1 | Homo sapiens (human) | IC50 | 27.2850 | 2 | 2 |
| Microtubule-associated proteins 1A/1B light chain 3A | Homo sapiens (human) | IC50 | 42.9000 | 1 | 1 |
| Microtubule-associated proteins 1A/1B light chain 3A | Homo sapiens (human) | Ki | 8.8000 | 1 | 1 |
| Microtubule-associated proteins 1A/1B light chain 3B | Homo sapiens (human) | IC50 | 172.0000 | 1 | 1 |
| Microtubule-associated proteins 1A/1B light chain 3B | Homo sapiens (human) | Ki | 19.3000 | 1 | 1 |
| Mitogen-activated protein kinase 10 | Homo sapiens (human) | IC50 | 22.2333 | 1 | 3 |
| Mitogen-activated protein kinase 14 | Homo sapiens (human) | IC50 | 22.2333 | 1 | 3 |
| Mitogen-activated protein kinase kinase kinase 8 | Homo sapiens (human) | IC50 | 2.3700 | 1 | 1 |
| MO15-related protein kinase Pfmrk | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 93.0000 | 1 | 1 |
| mothers against decapentaplegic homolog 3 isoform 1 | Homo sapiens (human) | IC50 | 0.1420 | 1 | 1 |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | IC50 | 0.5000 | 1 | 1 |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | IC50 | 17.9000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 95.7217 | 1 | 6 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | IC50 | 0.5700 | 1 | 4 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | IC50 | 0.5700 | 1 | 3 |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | IC50 | 0.5700 | 1 | 3 |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | IC50 | 0.5700 | 1 | 3 |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | IC50 | 0.5700 | 1 | 3 |
| Neuraminidase | Influenza A virus (A/Wilson-Smith/1933(H1N1)) | IC50 | 98.2667 | 3 | 3 |
| Non-structural protein 1 | Dengue virus | IC50 | 1.7000 | 1 | 1 |
| NUAK family SNF1-like kinase 1 | Homo sapiens (human) | IC50 | 0.5100 | 1 | 1 |
| Nucleophosmin | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Ornithine decarboxylase | Homo sapiens (human) | IC50 | 26.0000 | 1 | 1 |
| Oxysterols receptor LXR-alpha | Homo sapiens (human) | IC50 | 46.0000 | 3 | 4 |
| Oxysterols receptor LXR-beta | Homo sapiens (human) | IC50 | 48.0000 | 2 | 3 |
| Pancreatic alpha-amylase | Sus scrofa (pig) | IC50 | 200.0000 | 1 | 1 |
| Pancreatic triacylglycerol lipase | Sus scrofa (pig) | IC50 | 100.0000 | 1 | 1 |
| Phosphatidylcholine 2-acylhydrolase | Apis mellifera (honey bee) | IC50 | 0.0400 | 1 | 1 |
| Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN | Homo sapiens (human) | IC50 | 13.3000 | 1 | 1 |
| Phosphodiesterase isozyme 4 | Homo sapiens (human) | IC50 | 125.0000 | 1 | 1 |
| Phospholipase A2 | Apis mellifera (honey bee) | IC50 | 13.3571 | 7 | 7 |
| Phospholipase A2 | Homo sapiens (human) | IC50 | 3.9000 | 1 | 1 |
| Phospholipase A2, membrane associated | Homo sapiens (human) | IC50 | 320.9800 | 5 | 5 |
| Phospholipase A2, membrane associated | Rattus norvegicus (Norway rat) | IC50 | 1,019.2000 | 2 | 2 |
| Platelet-activating factor acetylhydrolase | Homo sapiens (human) | IC50 | 3.9000 | 1 | 1 |
| Platelet-derived growth factor receptor beta | Homo sapiens (human) | IC50 | 1.3000 | 1 | 1 |
| Polypeptide N-acetylgalactosaminyltransferase 2 | Homo sapiens (human) | IC50 | 1.7200 | 2 | 2 |
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | IC50 | 2.5000 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | IC50 | 0.9500 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Homo sapiens (human) | IC50 | 1.4000 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | IC50 | 9.0330 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 1,014.8287 | 17 | 27 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | Ki | 125.0000 | 1 | 2 |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | IC50 | 80.0000 | 1 | 1 |
| Protease | Human immunodeficiency virus 1 | IC50 | 219.0000 | 1 | 1 |
| Proteasome subunit beta type-5 | Homo sapiens (human) | IC50 | 37.1300 | 2 | 2 |
| Protein kinase C alpha type | Homo sapiens (human) | IC50 | 56.8750 | 2 | 8 |
| Protein kinase C beta type | Homo sapiens (human) | IC50 | 150.0000 | 1 | 1 |
| Protein kinase C epsilon type | Homo sapiens (human) | IC50 | 150.0000 | 1 | 1 |
| Proto-oncogene tyrosine-protein kinase receptor Ret | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Proto-oncogene tyrosine-protein kinase Src | Homo sapiens (human) | IC50 | 31.0667 | 6 | 6 |
| Pyruvate kinase PKM | Homo sapiens (human) | IC50 | 0.9000 | 1 | 1 |
| RAC-alpha serine/threonine-protein kinase | Homo sapiens (human) | IC50 | 36.6700 | 2 | 2 |
| Receptor tyrosine-protein kinase erbB-2 | Homo sapiens (human) | IC50 | 3.5400 | 1 | 1 |
| Receptor-type tyrosine-protein kinase FLT3 | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Receptor-type tyrosine-protein phosphatase epsilon | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| Receptor-type tyrosine-protein phosphatase eta | Homo sapiens (human) | IC50 | 111.5000 | 1 | 1 |
| Regulator of G-protein signaling 17 | Homo sapiens (human) | IC50 | 27.9338 | 5 | 5 |
| Renin | Homo sapiens (human) | IC50 | 0.9800 | 1 | 1 |
| Replicase polyprotein 1ab | Betacoronavirus England 1 | IC50 | 7.6000 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 10.3000 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | IC50 | 10.3000 | 2 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | Ki | 4.2000 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | Ki | 4.2000 | 2 | 2 |
| Serine/threonine-protein kinase B-raf | Homo sapiens (human) | IC50 | 1.7600 | 1 | 1 |
| Serine/threonine-protein kinase pim-1 | Homo sapiens (human) | IC50 | 0.8500 | 1 | 1 |
| Serine/threonine-protein kinase PLK1 | Homo sapiens (human) | IC50 | 3.3400 | 1 | 1 |
| Serine/threonine-protein kinase PLK4 | Homo sapiens (human) | IC50 | 2.9700 | 1 | 1 |
| Sialidase | Clostridium perfringens | IC50 | 12.0500 | 1 | 1 |
| Sialidase-2 | Homo sapiens (human) | IC50 | 380.0000 | 1 | 1 |
| Signal transducer and activator of transcription 3 | Homo sapiens (human) | IC50 | 24.8000 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | IC50 | 16.9180 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 13.4420 | 1 | 1 |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | IC50 | 0.3950 | 1 | 1 |
| Solute carrier family 2, facilitated glucose transporter member 1 | Homo sapiens (human) | Ki | 7.0000 | 3 | 3 |
| Solute carrier family 2, facilitated glucose transporter member 4 | Mus musculus (house mouse) | IC50 | 20.0000 | 1 | 1 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Solute carrier family 22 member 6 | Homo sapiens (human) | IC50 | 0.2700 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | IC50 | 9.1201 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | Ki | 5.0000 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | IC50 | 3.8904 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | Ki | 2.9600 | 1 | 1 |
| Squalene monooxygenase | Rattus norvegicus (Norway rat) | IC50 | 2.0000 | 1 | 1 |
| Steroid hormone receptor ERR1 | Homo sapiens (human) | IC50 | 0.0100 | 1 | 1 |
| Steroid hormone receptor ERR2 | Homo sapiens (human) | IC50 | 0.3950 | 1 | 1 |
| Substance-K receptor | Cavia porcellus (domestic guinea pig) | IC50 | 77.1000 | 1 | 1 |
| Substance-P receptor | Cavia porcellus (domestic guinea pig) | IC50 | 77.1000 | 1 | 1 |
| SUMO-conjugating enzyme UBC9 | Homo sapiens (human) | IC50 | 11.2000 | 2 | 2 |
| SUMO1 activating enzyme subunit 1 | Homo sapiens (human) | IC50 | 11.2000 | 2 | 2 |
| Tat | Human immunodeficiency virus 1 | IC50 | 1.6690 | 1 | 1 |
| Telomerase reverse transcriptase | Homo sapiens (human) | IC50 | 0.7800 | 1 | 1 |
| Telomere resolvase ResT | Borreliella burgdorferi B31 | IC50 | 8.6700 | 1 | 1 |
| Testosterone 17-beta-dehydrogenase 3 | Homo sapiens (human) | IC50 | 31.3500 | 1 | 2 |
| Thioredoxin reductase 1, cytoplasmic | Homo sapiens (human) | IC50 | 176.8000 | 2 | 2 |
| Thioredoxin reductase 2, mitochondrial | Homo sapiens (human) | IC50 | 176.8000 | 2 | 2 |
| Thioredoxin reductase 3 | Homo sapiens (human) | IC50 | 176.8000 | 2 | 2 |
| Thromboxane-A synthase | Homo sapiens (human) | IC50 | 7.7200 | 1 | 1 |
| Tissue alpha-L-fucosidase | Bos taurus (cattle) | IC50 | 54.0000 | 1 | 1 |
| Transcription factor p65 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Translin-associated protein X | Homo sapiens (human) | IC50 | 3.5000 | 1 | 1 |
| Transthyretin | Homo sapiens (human) | IC50 | 7.8000 | 1 | 1 |
| Triosephosphate isomerase | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| Triosephosphate isomerase | Oryctolagus cuniculus (rabbit) | Ki | 123.0000 | 1 | 1 |
| Triosephosphate isomerase, glycosomal | Trypanosoma cruzi | IC50 | 6.5000 | 1 | 1 |
| Tryptophan 2,3-dioxygenase | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Tubulin alpha-1A chain | Homo sapiens (human) | IC50 | 11.2700 | 1 | 1 |
| Tubulin alpha-1B chain | Homo sapiens (human) | IC50 | 11.2700 | 1 | 1 |
| Tubulin alpha-1C chain | Homo sapiens (human) | IC50 | 11.2700 | 1 | 1 |
| Tubulin alpha-3C chain | Homo sapiens (human) | IC50 | 11.2700 | 1 | 1 |
| Tubulin alpha-3E chain | Homo sapiens (human) | IC50 | 11.2700 | 1 | 1 |
| Tubulin alpha-4A chain | Homo sapiens (human) | IC50 | 11.2700 | 1 | 1 |
| Tubulin beta chain | Homo sapiens (human) | IC50 | 11.2700 | 1 | 1 |
| Tubulin beta-1 chain | Homo sapiens (human) | IC50 | 11.2700 | 1 | 1 |
| Tubulin beta-2A chain | Homo sapiens (human) | IC50 | 11.2700 | 1 | 1 |
| Tubulin beta-2B chain | Homo sapiens (human) | IC50 | 11.2700 | 1 | 1 |
| Tubulin beta-3 chain | Homo sapiens (human) | IC50 | 11.2700 | 1 | 1 |
| Tubulin beta-4A chain | Homo sapiens (human) | IC50 | 11.2700 | 1 | 1 |
| Tubulin beta-4B chain | Homo sapiens (human) | IC50 | 11.2700 | 1 | 1 |
| Tubulin beta-6 chain | Homo sapiens (human) | IC50 | 11.2700 | 1 | 1 |
| Tubulin beta-8 chain | Homo sapiens (human) | IC50 | 11.2700 | 1 | 1 |
| Tyrosinase | Mus musculus (house mouse) | IC50 | 500.0000 | 1 | 1 |
| Tyrosine-protein kinase ABL1 | Homo sapiens (human) | IC50 | 41.6667 | 3 | 9 |
| Tyrosine-protein kinase ABL2 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Tyrosine-protein kinase CSK | Homo sapiens (human) | IC50 | 50.7143 | 1 | 7 |
| Tyrosine-protein kinase Fgr | Rattus norvegicus (Norway rat) | IC50 | 3.5000 | 1 | 1 |
| Tyrosine-protein kinase Fyn | Homo sapiens (human) | IC50 | 31.6805 | 2 | 2 |
| Tyrosine-protein kinase Lyn | Rattus norvegicus (Norway rat) | IC50 | 7.5000 | 1 | 1 |
| Tyrosine-protein kinase SYK | Homo sapiens (human) | IC50 | 27.0000 | 2 | 2 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | IC50 | 5.4000 | 4 | 4 |
| Tyrosine-protein phosphatase non-receptor type 11 | Homo sapiens (human) | IC50 | 3.5667 | 3 | 3 |
| Tyrosine-protein phosphatase non-receptor type 2 | Homo sapiens (human) | IC50 | 20.9000 | 2 | 2 |
| Tyrosine-protein phosphatase non-receptor type 6 | Homo sapiens (human) | IC50 | 15.4500 | 2 | 2 |
| Tyrosine-protein phosphatase non-receptor type 7 | Homo sapiens (human) | IC50 | 75.7000 | 1 | 1 |
| Ubiquitin carboxyl-terminal hydrolase 15 | Homo sapiens (human) | IC50 | 31.4000 | 1 | 5 |
| Ubiquitin carboxyl-terminal hydrolase 2 | Homo sapiens (human) | IC50 | 31.4000 | 1 | 5 |
| Ubiquitin carboxyl-terminal hydrolase isozyme L1 | Homo sapiens (human) | IC50 | 31.4000 | 1 | 5 |
| Ubiquitin carboxyl-terminal hydrolase isozyme L3 | Homo sapiens (human) | IC50 | 31.4000 | 1 | 5 |
| Ubiquitin carboxyl-terminal hydrolase isozyme L5 | Homo sapiens (human) | IC50 | 31.4000 | 1 | 5 |
| Ubiquitin-like modifier activating enzyme 2 | Homo sapiens (human) | IC50 | 11.2000 | 2 | 2 |
| unnamed protein product | Aspergillus oryzae RIB40 | IC50 | 52.7195 | 2 | 2 |
| Vascular endothelial growth factor receptor 2 | Homo sapiens (human) | IC50 | 0.7900 | 1 | 1 |
| Vascular endothelial growth factor receptor 3 | Homo sapiens (human) | IC50 | 1.5400 | 1 | 1 |
| Vif | Human immunodeficiency virus 1 | IC50 | 0.4500 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Bos taurus (cattle) | IC50 | 1.7300 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Homo sapiens (human) | IC50 | 412.2767 | 3 | 3 |
| Zinc finger protein GLI1 | Homo sapiens (human) | IC50 | 32.0000 | 2 | 2 |